Follistatin 344

It’s an inhibitor of transforming growth factor-beta superfamily ligands that normally repress skeletal muscle growth plus promote muscle wasting. Consequently, follistatin, which is also called activin-binding protein, has surfaced as a potential curative to better muscle atrophy effects.

Research with macaque monkeys in 2009 showed that regulating follistatin through gene therapy led to muscle growth and increase in strength. The research paved way for human being clinical trials

In the setting of a disease, increasing expression in the musculature has shown to be beneficial for improving pathology aspects in mice with dystrophin-deficiency that model BMD and DMD (Becker and Duchenne muscular dystrophy). Also, recombinant follistatin administration has proven to increase muscle hypertrophy in wild mice, and also ameliorate a mouse model progression of SMA (spinal muscular atrophy).