GRF 1-29 (Sermorelin)

GRF 1-29 or Sermorelin is a GSH (growth hormone secretagogue), meaning that it stimulates hypophysis (pituitary gland) to produce as well as secrete human growth hormone. It’s a form of GRF containing only the first twenty-nine amino acids.
GRF that’s produced by neurosecretory neurones in your brain contains a total of 44 amino acids. However, only the first twenty-nine amino acids play the role of stimulating the production of pituitary and human growth hormone secretion.

GRF 1-29 has highly particular receptors on pituitary somatotrophs. Therefore, GRF 1-29 binds to the specific cells that produce as well as release human growth hormone. Upon binding, GRF 1-29 acts through a cylicAMP (cyclic adenosine monophosphate) second messenger system similar to that used by the naturally occurring GHRH (growth hormone releasing hormone).

Moreover, it has an exceptional safety profile. Sermorelin effects are often regulated at the pituitary gland level by negative feedback plus by somatostatin release, hence there are fewer safety concerns like those linked to overdosing of human growth hormone.

Tissue exposure to human growth hormone released by the pituitary Sermorelin influence mimics normal physiology. Basically, by stimulating your pituitary, it ends up preserving more of the GH neuroendocrine axis that declines with ageing.

GRF 1-29 is a complex way, it helps preserve your youthful physiology and youthful anatomy; it gives you all the benefits you get from human growth hormone and more.

Another sermorelin advantage is that it causes your pituitary gland to start up-regulating. This stimulates your gland to rejuvenate. Numerous reports in scientific and peer-reviewed medical literature show that RF/Sermorelin has a direct effect on your brain to promote non-REM SWS (slow wave sleep).